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Description

Xu M, Lu C, Han W

Direct evidence from multi-omics analyses of airway host-microbe interactions in COPD patients indicated that indole-3-acetic acid (IAA) derived from airway microbiota alleviated neutrophil inflammation, cell apoptosis, emphysema, and lung function decline through IL-22-mediated macrophage-epithelial cell interactions

In both trials, subjects were treated with Opzelura or placebo cream twice daily for 24 weeks, followed by an additional 28 weeks of treatment with Opzelura for all subjects