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Once formed, AGEs can damage cellular structures through a number of mechanisms, including the formation of cross-links between key molecules of the basement membrane of the extracellular matrix and interaction with receptors on cell surfaces, leading to this way to alteration of cellular function [36, 37]

Key agents are summarized in Table 2

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If you are uncertain about the best timing for your specific medication, consult your GP, practice nurse, or diabetes specialist nurse for personalised advice tailored to your treatment regimen and lifestyle

Research utilizing animal models of melanoma (Le Gal et al