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Despite identified positive relationships between vitamin B12 (B12) and mitochondrial biology, the impact of B12 supplementation on skeletal muscle mitochondria, in advanced age, has not been examined

Vegans, heavy drinkers, people over 50, and those on antacids face higher risk of B12 deficiency

Why isnt the lower reference limit, worldwide, at least 500 ng/L

543 Multidisciplinary care models involving endocrinologists, neurologists, podiatrists, nephrologists, ophthalmologists, cardiologists, dietitians, and physical therapists improve patient outcomes by addressing all aspects of health comprehensively, thereby reducing hospitalizations and healthcare costs

As a multifactorial, incurable disease, the exact causes of IBD remain unknown and vary between individuals but are thought to include an individuals genetic susceptibility, environmental factors such as diet, gut microbiome, and host immune responses

If your levels are already adequate, megadosing won't give you a noticeable boost