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Fresh tissue damage still has the cellular machinery for repair actively engaged, while chronic injuries may have entered a degenerative plateau

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Histamine H Receptor Antagonist (H 2 RA)/Proton Pump Inhibitor (PPI) Induced Vitamin B 12 Depletion Literature suggests that drugs which suppress stomach acid production such as PPIs 159163 and HRAs 164167 interfere with vitamin B 12 absorption, by reducing dietary B12 release from food proteins

The polarization state of macrophages dictates their propensity to exhibit pro- or anti-inflammatory characteristics