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Further exploration found that ISA could lower the plasma levels of IL-6 and TNF-, which are also closely associated with depression (Wang et al., 2023

doi:10.1016/j.jacc.2018.02.072 Shu XJ, Li ZF, Chang YW, Liu SY, Wang WH

Mitochondria affect ferroptosis at the level of the cytosolic iron pool regulation by fine-tuning the iron influx from the cytosol into mitochondria, at the level of electron transport chain by adjusting mitROS generation and oxidative phosphorylation via AMPK activation in the energy-deficient state, and at the level of tricarboxylic acid (TCA) cycle affecting the content of NADPH and GSH [162, 166]

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Cell 157 , 15771590 (2014)