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For example, it has been reported that activates the AMP-activated protein kinase (AMPK) (82), while the main regulatory factor is adaptability of the skeletal muscle oxidative metabolism, but interferes with mammalian target of rapamycin complex 1 (mTORC1) signaling, a major regulator of skeletal muscle hypertrophy (83, 84)

In conclusion, the transcriptome profiles have unveiled a possible mechanism of PC in alleviating PE, through which PC may alleviate PE by restoring metabolic homeostasis and improving energy metabolism

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Alternatively, the increased QUIN/KYN ratio in PTSD could also derive from a different distribution of KYN in body compartments, such as increased passage of this molecule through the BBB or its recruitment for binding to the aryl hydrocarbon receptor (Ahr) that promotes ROS modulation, all of which could potentially occur during the induction of cytokine release and inflammation present in these patients (142)

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The same is true for another myeloproliferative disorder: in blast crisis of chronic myeloid leukemia we have found the correlation of the expression of functionally active Pgp and the expression of the antigens of early myeloid differentiation--CD34 and CD13 [33]