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Su X, He Y, Li H, et al

One major challenge in finding effective treatment targets is that existing models often fail to accurately represent tissue diversity, interactions between tumors and surrounding tissues, and the role of the immune system

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Suppression of antitumor immunity by IL-10 and TGF-beta-producing T cells infiltrating the growing tumor: influence of tumor environment on the induction of CD4+ and CD8+ regulatory T cells