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These infiltrating cells predominantly exhibit an M1 phenotype, especially TREM2 + CD68 + macrophage subgroups, which secrete TNF-, IL-6, and high levels of MMP-9, aggravating the inflammatory storm and disrupting the axonal guidance microenvironment (Candelario-Jalil et al., 2007)

10.1210/edrv.23.2.0461 103 LiB.-y.LiX.-l.GaoH.-q.ZhangJ.-h.CaiQ.ChengM.et al (2011)