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Collectively, it may be hypothesized that obesity induces feedback inhibition of pituitary GH secretion by increasing non-fasting serum FFA levels and the associated insulin resistance that causes compensatory intra-portal hyperinsulinemia and IGFBP-1 suppression, with the net result being low GH and normal IGF-I levels

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M., & Masrur, S

In gastric cancer, the RNA demethylase ALKBH5 (Alkylated DNA repair protein alkB homolog 5) removes an m 6 A modification from CHAC1 mRNA, a mark normally associated with transcript stability

Phenotype-specific enrichment of mendelian disorder genes near GWAS regions across 62 complex traits