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The process of wound healing requires strict regulation, and its disruption can lead to the formation of chronic wounds, which can have a significant impact on an individuals health as well as on worldwide healthcare expenditure

Furthermore, the alterations of the metabolic state impact cellular senescence and SASP, which in turn provoke metabolism disorders and even metabolic diseases [174]

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This system, together with palpation of the emergence sites of the pericranial nerves, may assist in the diagnosis of the corresponding neuralgias, which may be treated with anaesthetic block.30,48 Similarly, cervical nerve branch involvement should be considered if pain extends to the back of the skull, back of the ear, or mandibular angle.49,50 Pharmacological treatment of trigeminal neuralgia Carbamazepine is the only drug with class I evidence (grade of recommendation A)