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Our model suggests that the large male-female differences in GSH concentration and the velocity of its synthesis cause females to be less sensitive to APAP toxicity compared to males

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In addition, esculin induces endoplasmic reticulum stress through the regulation of eukaryotic translation initiation factor 2/CHOP and Nrf2/HO-1 pathways via the PERK signaling pathway

Strikingly, Gclc ablation increased mTORC1 activation in FoB to a level similar to that found in MZB

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doi: 10.1146/annurev.bi.52.070183.003431 192 MinichD