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Furthermore, enhanced treatment efficacy was confirmed for high-dose VitC in combination with several hormonal treatments such as oestrogen receptor ER and human epidermal growth factor receptor 2 (HER2) inhibitors in breast cancer cells [108], as well as for PARP inhibition in the treatment of AML-TET2 deficient cells [22] and JQ1 (thieno-triazolo-1,4-diazepine), a Bromodomain and extraterminal inhibitor, in the treatment of melanoma [36]

[21] A meta-analysis of folate supplementation during pregnancy reported a 28% lower relative risk of newborn congenital heart defects

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The inhibition of UCP2 upregulation resulted in the reduction of mtROS production and promotion of ATP generation in prohibitin-overexpressing H 2 O 2 -induced injury of proximal tubular cells [44]