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"GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration"

PubMed record Khavinson VK

There is one Phase I trial registered as NCT02637284 in 2015, intended to enrol forty-two participants, which was subsequently cancelled with no published results [7]

Its stability-enhancing N-terminal modification allows for effective subcutaneous administration, and it is FDA-approved for HIV-related lipodystrophy

Kolovrat et al., 2020) and venous thrombosis (Vukojevic et al., 2018

Clinical trials show moderate-to-large effects (e.g., 25-35% wrinkle/scar improvements), though limited by sample sizes and short durations