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Immunofluorescence staining of -syn and p--syn showed that aggregates formed in the cytoplasm and axons of neurons after hypoxic treatment

While various chemical ligation methods are available, they are typically limited to short fragments and are often inefficient for long-range RNA ligation or result in the formation of non-canonical (unnatural) linkages within the mRNA [317,318,319]

Likewise, the European Medicines Agency (EMA) has introduced a suite of incentives, including market exclusivity, fee reductions, and scientific advice, to stimulate orphan drug development