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FIGURE 5 One of the best-known representatives of SOD mimetics is the drug 4-Hydroxy-TEMPO (TEMPOL), which had shown effectiveness in a number of preclinical and clinical studies of the treatment of autoimmune, cardiovascular diseases, and oncological diseases (Kim et al., 2016)

This benefit perhaps reflects the capacity of residual enzyme activity to be enhanced by the presence of the cofactor

doi: Trapp BD, Ransohoff R, Rudick R (1999) Axonal pathology in multiple sclerosis: relationship to neurologic disability

This failure precedes very early death of a select population of vulnerable neurons and the transformation of each of these dying neurons into an extracellular senile plaque (Fig

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