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The results showed that the expression of SIRT1, P-gp, and MRP1 was promoted by the low expression of hsa-miR-34a, which led to the development of MDR in GC cells

doi: 10.1073/pnas.2209944120 159 TredicineMRiaFPoerioNLucchiniMBiancoASantisFDet al

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These proteins mediate G2 phase arrest, preventing progression to the M phase ( BAX and BBC3 (PUMA) were downregulated, while anti-apoptotic genes such as BCL2 , XIAP and BIRC2 were upregulated with increased time on ART

Six h after seeding (or 24 h after doxycycline induction for IMR-5/75), the cells were treated with 100 L of drug(s) or vehicle and incubated at 37C