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There is some evidence for the association between maternal ID and preterm delivery [16], low birth weight [17], possible placental abruption, and increased peripartum blood loss [18]

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Nevertheless, to rule out the possibility that micronutrients exclusively present in plasma/physiological medium can compensate for or circumvent perturbation of riboflavin metabolism, we confirmed that RFK deletion in AML cells cultured in Plasmax phenocopied the effects of culture in RPMI, suggesting that this dependency is relevant in physiological systems (Figure 2F)

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While this preservative enhances its utility for multi-dose applications, it also means it may not be suitable for certain patients, such as neonates or those with sensitivities to alcohol-based agents

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