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however, it remains unclear how the BCL-2- and AR-expressing PCa cell populations evolve across the PCa continuum, how AR molecularly regulates BCL-2 and whether BCL-2 represents a common therapeutic target in heterogeneous CRPC

J.MallardB.et al

308 However, these treatments can cause side effects, such as systemic toxicity, unavoidable invasiveness, and a high risk of relapse

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In addition to the amino acid changes we saw a significant increase in 2-aminoadipic acid, which is produced by lysine degradation