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In a multicenter randomized, double-blind, placebo-controlled clinical trial, the effectiveness of rosiglitazone in managing UC with mild to moderate activity has been demonstrated (306)

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Unfortunately, the OCA treatment is increasingly associated with limiting adverse effects like pruritus and fatigue

Current studies mainly focus on combinations with dietary control, exercise, and other weightloss agents, aiming to enhance efficacy and reduce side effects

Redesign of genetically encoded biosensors for monitoring mitochondrial redox status in a broad range of model eukaryotes