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Decreased Intake issues: A vegan or vegetarian diet with no animal products Poor Absorption Issues Medications that block absorption of B12 Pernicious anemia Auto-immune disorders An Helicobacter pylori (H

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A can interfere with axonal transport through mechanisms that do not rely on tau or destabilization of microtubules, involving factors such as NMDA receptor activation, casein kinase 2 or calcineurin (Vossel et al., 2015)

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This TYR-catalyzed PROTAC design facilitates the in-situ cross-linking of two small molecules for targeted protein elimination, bypassing the need for prior covalent conjugation and mitigating issues of large molecular weights and unfavorable pharmacological properties of traditional PROTAC design