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Reduced GPX4 expression in turn means that this protective system is reduced and thus enhancing susceptibility of chondrocytes to oxidative stress via MAPK/NF-B signaling (Liu et al., 2024)

Initial mitochondrial ROS production triggers calcium release from intracellular stores, which, in turn, further stimulates mitochondrial ROS production while activating calcium-dependent proteases and phospholipases ( Cell death pathways Hair cell death proceeds through multiple interacting mechanisms, with the dominant pathway determined by drug concentration, exposure duration, and cellular stress levels

(2017) 2:e356e66

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