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[5], metformin was associated with a significantly increased risk of vitamin B12 deficiency starting in the fourth year of treatment

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The age-specific average daily intakes, expressed in micrograms (mcg), are as follows: Vitamin B12 deficiency is present in approximately 1.5% to 15% of the population, with varying percentages depending on age groups: Physical, neurological, and psychological problems can occur from the effects of Vitamin B12 deficiency