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Low-grade systemic inflammation driven by several mediators previously debated, such as LPS, bacterial translocation and the increased proinflammatory cytokines and Th1 response, are all contributing to an immunological response in the brain [139]

J Essen Oil Bearing Plants 22:13331348

M., Ghigiarelli, J

Discovery of pterostilbene analogs as novel NLRP3 inflammasome inhibitors for potential treatment of DSS-induced colitis in mice

If your goal involves gastrointestinal healing, the peptide contacting intestinal tissues directly could provide benefit even if it never reaches the bloodstream