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The purpose of this review is to look at the evidence available for supporting the use of arginine in such patients, either as a standalone agent or in combination with other molecules

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Three of the patients received atorvastatin, and one each received fluvastatin, rosuvastatin, lovastatin, and simvastatin

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Acknowledgments The authors would like to thank Aouatef Bellamine, for her help with study management and Suzanne Morris, at Concrete Medical Writing, LLC, for providing medical writing support (funded by Lonza)

In order to minimize bias, we only included studies that had large sample sizes (96987 children per study