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Rights and permissions Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made

The distance that each mouse travelled and the proportion of time spent exploring the central 45 cm of the field were determined

Xia et al

Biologia 76 (1), 351365

Additionally, in Alzheimer's disease models where neuronal dysfunction was induced by intracerebroventricular injection of A 142, treatment with nicotinamide (NAM) effectively prevented memory deficits (210)