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Oxidative phosphorylation The primary function of mitochondria is energy production, with the majority of ATP being generated through OXPHOS

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However, Aja and colleagues found no evidence for this hypothesis since in this model CPT-1 should inhibit feeding by increasing cytosolic fatty-acyl CoA levels while they actually showed the initial response of mice to a CPT-1 inhibitor was an increase in appetite [75]

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After Mtb infection of human macrophages, NOD2 activation increases iNOS synthesis and activity, indicating a novel molecular pathway