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Especially, phenolic compounds have dual roles as antioxidants and as substrates for oxidative browning reactions with oxidoreductases, including polyphenol oxidase (PPO) and POD 41

FN1 rs1250248 is implicated in the angiogenic pathway, WNT4 rs7521902 in embryonic development, GREB1 rs13394619 in the hormonal pathway, VEZT rs10859871 in cytoskeleton regulation [75], and IL1A rs6542095 in various immune responses and inflammatory pathways [76]

This article is one of the first to provide a comprehensive overview of brain ischaemia and multimodal strategies for targeting various cellular mechanisms following ischaemic injury