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The excessive infiltration of SMs into synovia causes articular immune dysfunction, accelerates the progression of synovitis, and leads to osteoclast activation and ultimate bone erosion and joint destruction 7,8

Biochem Pharmacol 119:7684 Shimada T, Yamazaki H, Mimura M, Inui Y, Guengerich FP (1994) Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians

[3] PubMed

Erastin inhibits system Xc to lower GSH, reverses the Warburg effect, and thus primes mitochondria to amplify copper-mediated cuproptosis, culminating in irreversible mitochondrial damage

It reduces insulin resistance, inflammation, and oxidative stress while protecting against age-related diseases like cancer and cardiovascular issues

Overweight and Obesity Are Positively Associated with Serum Copper Levels in Mexican Schoolchildren