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It uses genetic variation as a tool variable to derive the causality of outcome and exposure, and is an effective method used to conduct causal inference, and can effectively avoid the confounding bias in traditional epidemiological studies

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Worry about health consequences has been reported to be associated with motivation or intention to quit smoking, in a population study in England 35 , which explains individuals who downplay the health risks associated with smoking may exhibit higher levels of nicotine dependence

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