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cerevisiae PNS1 (pH nine-sensitive protein 1), and Arabidopsis thaliana CherI (Choline Transporter-like 1) (23, 24)

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Vinpocetine, a synthetic derivative of the vinca alkaloid vincamine, attenuated Mn-induced oxidative stress and apoptosis in rats ( Edaravone (Radicava), an FDA-approved drug for treating stroke and amyotrophic lateral sclerosis (ALS) ( In addition to its chelating properties on Mn, PAS exerted protective effects against Mn-induced neurodegeneration by enhancing antioxidant, anti-inflammatory, anti-excitotoxicity, and antiapoptotic effects in various in vitro and in vivo experimental models (Zheng et al., 2009

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These animals were weaned as per normal at 3 weeks of age onto normal drinking water or water containing NMN (2 g/L)