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[8] Early small-scale research suggested it may stimulate lipolysis (the breakdown of fat) and inhibit lipogenesis (fat storage), with preliminary data indicating it may not significantly affect blood glucose or insulin-like growth factor-1 (IGF-1) levels

doi:10.1038/labinvest.2013.52

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Melatonin mechanisms of action and effects need much further work, to better understand the therapeutic value of melatonin and its potential applications

While clinical benefit was observed in the groups randomized to brodalumab, this study was not adequately powered to determine the optimal dose and regimen required for treatment of PsA