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The Impact of Keap1/Nrf2, P38MAPK/NF-b and Bax/Bcl2/caspase-3 Signaling Pathways in the Protective Effects of Berberine against Methotrexate-Induced Nephrotoxicity

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The induction of melatonin synthesis in rodents and human macrophages by the transcription factor is a hallmark in inflammatory responses and inflammation ( During the mounting of an innate immune response melatonin plays various roles: the reduction of nocturnal melatonin leads to the mobilization of leukocytes from the bone marrow to the blood, and from the blood to the site of lesion