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Their effects on the cardiovascular system are likely mediated through the activation of calcium/calmodulin-dependent kinase II (CaMKII) expression within the PVN and key cardiovascular control regions [32]

Chem Sci (2018) 9(10):267489

The distinction matters: acute flushing rarely requires treatment beyond avoiding triggers, while chronic flushing usually signals an underlying condition

As a result of this impaired skin barrier function, enhanced penetrability of the drugs via stratum corneum has been observed [13]

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