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Steroidogenic Factor-1 (SF-1, encoded by NR5A1), Forkhead box O1 (FOXO1) and Liver receptor homolog-1 (LRH-1, encoded by NR5A2) play essential functional roles within this network ( SF-1 is a key nuclear receptor transcription factor, which controls the development and the functionality of steroidogenic tissues including the adrenal glands, and gonads and is coded by the NR5A1 gene ( Steroid-genic factor-1 (SF-1) transcription factor is upregulated in the process of granulosa-cell differentiation and luteinization, which in turn suggests that SF-1 is essential to the process of specification of granulosa-cell into luteal cells ( SF-1 regulation is performed in two ways: direct transcriptional activity and associations with various co-regulators and signaling cascades

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Glutathione levels naturally decline with age, illness, and oxidative stress

Then T ECM , EDC, and NHS were added to PEI-PPS nanoparticle solution to obtain T ECM modified nanoparticles (T ECM -NS)