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In addition, the glutaminase inhibitor IPN60090 can be combined with CB839 in the treatment of Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML), and with increasing doses of CB839 and IPN60090, the levels of intracellular NADPH and NADP+ are reduced, thereby inhibiting the proliferation of MDS and AML cells [72]

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doi: 10.1002/bbb.2273

Supplementary material The Supplementary Material for this article can be found online at: Supplementary Figure 1 Correlation between substances: red is positive correlation, blue is negative correlation

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Additionally, environmental factors such as iodine excess or deficiency, smoking, stress, exposure to chemicals, medications (e.g., amiodarone, interferon-), and some viral/bacterial infections can alter gene expression patterns through epigenetic mechanisms and trigger autoimmune processes