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These conditions are characterized by chronic relapses and require lifelong treatment, with an increased risk of malignancy, resulting in significant psychological and physiological impacts on patients [1, 2]

Pharmacol., 67: 49-54

(2015) 10:e0119316

coli infection induced local changes in the peritoneum alone, not in the plasma or lungs ( Above all, advanced host types of machinery protect cells by detecting and preventing damage due to intrinsic and exogenous inferior substances, such as oxidative stress and toxins ( Keap1-Nrf2 Signaling Pathway The Keap1-Nrf2 regulatory pathway is a key mechanism for preventing cell damage by detecting intrinsic and exogenous stresses, such as oxidative stress, chemotherapy, and radiation, regulating gene expression to modulate various subsequent antioxidant functions ( Figure 2 ) ( via activation of the Keap1-Nrf2 signaling cascade (95)

& Gmeiner, P

doi: 10.3892/ol.2020.12237 206 RushworthGFMegsonIL