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Efficacy and safety of the PPAR partial agonist balaglitazone compared with pioglitazone and placebo: a phase III, randomized, parallel-group study in patients with type 2 diabetes on stable insulin therapy

Patients with S and Z polymorphisms have significantly lower values of free copper, not bound to ceruloplasmin, as well as an alteration of zinc homeostasis

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This approach is superior to taking vitamins orally because unlike the gut, the entire amount is absorbed through the body