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Once GSH is depleted, ROS and reactive nitrogen species escalate, leading to increased oxidative stress, mitochondrial dysfunction, and DNA damage

With the advent of new technologies and a deeper understanding of neuronal metabolism, the field is poised for significant breakthroughs that could transform our approach to treating neurological disorders (Lee and Silva, 2009)

The strategies to deal with these problems are discussed, aiming at the modification of nanocarriers, stimuli-sensitive systems, and immunomodulatory approaches

doi: 10.3390/pharmaceutics11010022

Int J Mol Sci 25:12366

Current Limitation and Challenges Despite knowledge gained and discussed above and the tremendous clinical success in cancer therapy in the present era, the clinical application of genistein as a promising therapeutic agent for cancer treatment is not fully understood