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Cell death in the cystine-deprived high MYCN cells was not abrogated by the inhibition of (1) caspases to prevent apoptosis, (2) lysosomal function to downregulate autophagy or (3) receptor-interacting serine/threonine-protein kinase 1 (RIPK1) to prevent necroptosis (Extended Data Fig

[DOI] [PMC free article] [PubMed] [Google Scholar] 65.Brinkmann V., Zychlinsky A