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Its research profile centers on mitochondrial retrograde signaling, where the peptide is thought to help regulate how cells adjust energy production in response to metabolic stress, independent of any hormone-receptor cascade

The latter possibly points to one of the compensatory mechanisms that limits long-term efficacy of bupropion and other weight loss modalities

10.1016/S0140-6736(98)04197-X [DOI] [PubMed] [Google Scholar] 32

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The proposed mode of action of AOD 9604 has been suggested by researchers to be restricted to promoting lipolysis, thus linking the synthetic compound to obesity research