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In contrast, NOX 4 plays important roles in endogenous detoxification reactions, angiogenesis, ERS, substrate utilization, and stress responses (40)

Thyroid-hormone-disrupting chemicals: Evidence for dose-dependent additivity or synergism

J Immunol 185(8):49044911 Tadokoro T, Ikeda M, Ide T, Deguchi H, Ikeda S, Okabe K, Ishikita A, Matsushima S, Koumura T, Yamada KI, Imai H, Tsutsui H (2020) Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity

2b rather than H-site (ARG155, ARG69, THR68, LEU72, HIS159, ILE96, ALA100, SER18) as expected from X-ray data shown in Fig