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However, extensive studies are still required before a definitive conclusion can be reached

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4.1 Key molecular pathways ROS-induced in NSCs 4.1.1 NRF2 signalling Nuclear factor erythroid 2-related factor 2 (NRF2) has emerged as it represents the master regulator of the cellular defense against oxidative stress

Among the investigated genes, nine were down-regulated and two were up-regulated, including the LF gene

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Cross-sectional studies have shown that plasma and tissue glutathione concentrations decrease by approximately 10-15% per decade after age 45, and this decline is accelerated in conditions associated with chronic oxidative stress, including type 2 diabetes, cardiovascular disease, neurodegenerative diseases, HIV/AIDS, chronic liver disease, and chronic obstructive pulmonary disease (COPD) [2][3][10][11]