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J Neurochem 52: 876883

Accepted January 2013

These properties of CaSR have particularly attracted research in the field of food chemistry because GSH and -Glu-Val-Gly act as kokumi taste substances that enhance sweetness, saltiness, and umami tastes without producing a taste of their own [168]

This results in oxidative stress which hinders not only the production of thyroid hormones, but also the conversion of T4 into the active T3 form used by cells

Thus, structures of glutathionylated glutaredoxins 31,43,44,45 most likely resemble enzyme species F, whereas similar structures of complexes between reduced glutaredoxin and GSH with longer sulfursulfur distances 24,46 do not represent the interaction with GSH (but probably also resemble species F)