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Description

Ren J, Zhang Y

2023;9:eadc9465

Intranasal administration, though less studied with Dihexa specifically, would theoretically provide the most direct CNS delivery with minimal systemic exposurepotentially requiring even less frequent dosing to maintain effective brain tissue concentrations

London: John Churchill

Procedures may require multiple sessions spaced a few weeks apart, typically required to achieve optimal results

Carbon monoxide (CO), a major metabolite of HO-1, has been reported to stabilize the HIF-1 protein via translational suppression of HIF-1 ubiquitination 61,62