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Phase 1 clinical trial using mbIL21 ex vivo -expanded donor-derived NK cells after haploidentical transplantation

These compositional shifts are typically accompanied by decreased short-chain fatty acid synthesis and abnormal bile acid metabolism, which may indirectly mediate MPs toxic effects on distant organsincluding the liver and brainthrough low-grade inflammation and metabolic disturbances [67]

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[4] Note: in 1874, Jacobus Henricus van t Hoff and Joseph Achille Le Bel, building on Pasteurs work, were the first to propose the theory of the tetrahedral carbon atom

Future longitudinal studies that correlate symptoms fluctuations with alterations in these pathways could also help identify new therapeutic targets