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In a stressed state, such as in ischemia/reperfusion (I/R) injury models, ERR deficiency exacerbates oxidative stress and decreases mitochondrial autophagy

Vitamin B6 Why it matters: Vitamin B6 is a cofactor in more than 140 reactions, including those that regulate protein, fat, and glucose metabolism

Butterbur extracts possess analgesic, anti-inflammatory, anti-spasmodic, and vasodilatory properties, which may explain their efficacy for migraine prevention (Pothmann 2005

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For example, inhibition of respiration leads to a transcriptional switch in the expression of TCA cycle genes in fission yeast to replenish TCA cycle metabolites that support anabolic pathways (Liu and Butow, 1999)

Scuptra is often prescribed as the treatment of choice for HIV-positive patients who experience severe facial wasting (gaunt appearance) due to their illness