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The measure establishes 30 mL/kg of crystalloid fluids as the default volume for fluid resuscitation but does allow for lesser volumes ordered by a clinician and accompanied ( by documentation of a reason for administering a lesser volume in recognition that some patients may not tolerate 30 mL/kg and that others may respond adequately to a lesser volume

However, one should also keep in mind, that p53, generally activated in cellular stress controls, is also involvedbesides controlling the above mentioned metabolic pathwaysin other cellular key processes, like apoptosis, autophagy and cell proliferation through inhibition of Akt and mTOR (Liang et al., 2013)

Moreover, ROS-dependent angiogenesis can be induced through the activation of this pathway to lead to the expression of HIF1 and VEGF [45]

It is characterized by a sustained systolic blood pressure (SBP) of 130 mmHg or higher, or a diastolic blood pressure (DBP) of 80 mmHg or higher

Sources: Dixson et al