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10.1016/j.jconrel.2020.05.037 29 CumpelikA.AnkliB.ZecherD.SchifferliJ

Moreover, this study revealed for the first time that the downregulation of the mitochondrial biogenesis coactivator PGC-1 and its downstream nuclear factors are linked to mtDNA content in high-fat diet-induced obesity, muscle density loss, mitochondrial and myocardial contractile dysfunction, ROS accumulation, and intracellular Ca 2+ signaling

doi: 10.1111/j.1444-2906.2006.01215.x

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The most abundant free radical scavenger synthesized in humans, there is a wealth of evidence which demonstrates glutathione's status to be significant in a number of acute and chronic diseases