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Within the nucleus, NRF2 binds to promoter regions of target genes which contain antioxidant response element (ARE) sequences, ultimately inducing the transcription of cytoprotective genes, i.e., those encoding for phase II detoxification enzymes and antioxidants

Biomaterials 27, 59355943.10.1016/j.biomaterials.2006.08.029 125 RodellC

Broad Gene-Expression Signal (experimental): Reported studies show changes in gene sets tied to ECM remodeling, antioxidant defenses, inflammatory signaling, and nervous-system pathways

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Proc Natl Acad Sci USA 92: 63996403

The Pur Health exclusively uses pharmaceutical-grade B12 in two forms: methylcobalamin (the active, readily-usable form) and cyanocobalamin (the stable, synthetic form your body converts)