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16 Attachment The attachment of CTCs to ECs constitutes the first step before the subsequent extravasation process (Fig

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As analytical sensitivity continues to improve, integrative multi-omics approaches may enable the identification of key bioactive components within PDEVs, for example, miRNAs from tea-derived EVs exert anti-inflammatory effects by reprogramming macrophages [188]

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Therefore, continued rigorous research is needed

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However, their oral administration may compromise their iron-binding capacity due to metabolic transformations in the gastrointestinal tract and competition for iron by the gut microbiota [62]

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Circulation 147, 650666

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Conclusion: Overall, the Ldlr-/-.Leiden mouse model shows good clinical translatability and accurately mimics the etiology and pathology of NASH and fibrosis in humans

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